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Project group 7 


Project leader:

Prof. Dr. Frank Angenstein and Dr. Cornelia Helbing



c CBBS AngensteinThe hippocampus plays important roles in the consolidation of learning directed processes. Considerable evidence suggests that dopamine is involved in modulating the consolidation or retrieval of memory. Dopaminergic neurons of the midbrain are the major source of dopamine in the brain. Hippocampal activity is indirectly linked to the activity of dopaminergic neurons in the midbrain (ventral tegmental area and substantia nigra; VTA-SN) and controls by that the function of various structures in the mesolimbic system, such as the nucleus accumbens, the amygdala, the medial prefrontal cortex and eventually the hippocampus itself. Electrical stimulation of one major hippocampal output system, the fimbria-fornix, in combination with functional magnetic resonance imaging (fMRI) or fast scan cyclic voltammetry (FSCV) will reveal how altered hippocampal activity drives mesolimbic dopaminergic activity and how this in turn modifies hippocampal activity.

Thus, in this project we study how activation of the hippocampus-VTA loop affects brain wide neuronal networks. For that, a multimodal imaging approach is employed to examine global and local changes in neuronal activities that occur during defined electrical hippocampal fimbria-fornix stimulation in the rat brain. Changes in global neuronal network activity during electrical stimulation of the fimbria fibres will be visualized by fMRI and local neurochemical changes will be monitored by FSCV. Engineered designer receptors exclusively activated by designer drugs (DREADD) will be used to selectively silence dopaminergic neurons in the VTA to examine how a disturbed hippocampal-VTA loop modifies functional interactions of the hippocampus with various subcortical and cortical structures.

„Wissenschaft im Rathaus" - Stressbelastung, Konflikte und Mobbing am Arbeitsplatz als Risikofaktoren für psychische und psychosomatische Erkrankungen: Was können wir tun?

17.04.2024 - Am 29. April 2024, um 19 Uhr, spricht Dr. med. Florian Junne (Universitätsklinik für Psychosomatische Medizin und Psychotherapie Magdeburg)

Institutskolloquium Psychologie: Visual information processing in the human brain: The role of lateral occipital cortex in visual context integration

16.04.2024 - Am 23. April 2024, 17.15 Uhr im Geb.22a der OVGU, spricht PD Dr. Ralph Weidner (Research Center Jülich)

Eigenständiger Gedächtnistest per Smartphone kann Vorzeichen von Alzheimer erkennen

27.03.2024 - Digitaler Ansatz soll Weg für bessere Frühdiagnostik bereiten

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Otto-von-Guericke-Universität Magdeburg

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