eu efre logo

NeuroNetwork 6

 

Project tilte: Oxidative stress and mitochondrial dysfunction in dependence on protective paradigms in M. Alzheimer

Project leader: Elmar Kirches, Thomas Endres, Yannic Waerzeggers, Michael Gruß, Jörg Bock

 

nn6-1


Alzheimer’s disease (AD) is the most common neurodegenerative disorder of the central nervous system. Because disease risk increases with age, the growing expectancy of life will lead to a dramatic increase of cases in Europe and other parts of the world within the next decades. Besides an enormous psychological strain for the affected individuals, the disease will also cause a massive economic damage due to the high degree of disability of the patients. Although the scientific community currently favors a central role of an overproduction of the neurotoxic Aß-peptide in Alzheimers pathogenesis, first studies aiming to attack this pathway revealed disappointing results. The molecular details of pathogenesis still remain unclear.

 

Exploiting novel mouse models, this Neuronetwork investigates the role of decreased brain levels of the neurotrophic protein BDNF in AD pathogenesis, because a BDNF decline had been observed in patients earlier. Emphasis is laid on the efficiency of memory, which is explored by various learning paradigms. In addition, mitochondrial dysfunction and oxidative stress are analyzed. Following sufficient basic characterization, the disease models offer the possibility to evaluate strategies of neuronal protection, such as physical and mental stimulation, BDNF-substitution, receptor agonists or deep brain stimulation.

Call for tender: Paper of the Year 2020

Download Paper of the year 2020

08.03.2021 Overview of open positions

The OVGU and its partners are looking for support - apply now!

7. Internationale Conference of Auditory Cortex

ICAC organizers seek topics for virtual meetings.

open positions for PhD students and Postdocs and more

Open positions for HIWI, Bachelor, Master, MD, PhD students and Postdocs available.

press releases

Read more...

Members

Otto-von-Guericke-Universität Magdeburg

LIN Leibniz Institute for Neurobiology Magdeburg


Promoting young researchers

CBBS Graduierten Logo